Ignaz Semmelweis was ridiculed by the establishment for suggesting that doctors wash their hands before delivering a baby. Despite evidence that it worked, doctors refused to do so because it went against the consensus of the time, and pathogens had not been discovered. Point being that being a contrarian even with evidence will make you a pariah in the scientific community.
Herr Doktor Ignaz Semmelweis — poor guy had two strikes against him right there.