“I doubt any plane traveling at 4,602 mph could be manned.”
The space shuttle was.
The faster you go the higher you go. Anything going that fast would be WAY up where the air is almost not there.
I wad thinking in terms of an atmospheric craft like a fighter or bomber. Combat maneuvering at 4,602 mph other then using an entire continent to turn a corner would be hard n flesh and bones.