Ireland is the most American country in Europe (except for maybe Britain), so if they're not our friends, we could be in trouble.
But like Canada, Ireland has politicians who make their priority being hostile to the US.
Average Irishmen and Irishwomen probably aren't anti-American, though like most Europeans, they prefer the Democrats to the Republicans.
I went to a wedding there some years back. I was asked who I voted for in the recent election. After saying I voted for W I left the country 3 days early vowing to never return or speak to that part of my family again. Effem.