I am guessing drug-induced psycopathies. I could be wrong, but long-term drug abuse destroys the mind and could lead to things like this or variations. I think we should try to help drug addicts, but the majority either don’t want help or can’t shake addiction. A good reason to never try drugs.
On the flip side, many people with serious brain disorders to begin with, such as BiPolar disorder or Schizophrenia, Schizoaffective disorder, etc., often turn to drugs to “self medicate.” Have several family members in the class I’m currently teaching with loved ones in that terrible situation.