I guess it boils down to degree of safety you want to exercise. There are reasons for just about all carry options.
For the fastest operation, it would be either a Glock style trigger or a single action auto cocked and chambered with all safeties off. Cocked and locked would be nearly as fast and safer.
Chamber empty but magazine loaded is sometimes called for too. For example if I were to be visited by family members with young children who were not trained in gun safety I would keep a gun still handy but with an empty chamber.
I do remember reading many years ago of a Texas Ranger who carried his 1911 cocked, safety off and grip safety taped down.
I know that John Browning considered his hammerless (or internal hammer) autos to be safe to carry with a chambered round and the safety on.
Depends on the gun I am carrying.
For my 1911 and P238, I carry cocked and locked. Condition 1.
However, both of my Glocks use IWB holsters in the front of my pnts so that means when I am sitting, the gun is pointed at my femoral artery. Because of this, I carry Condition 3 Glocks. Rather safe than sorry.