yep, on a really bad day you might shoot a piston out the bottom of your engine or completely blow a cylinder.
That would be pretty much a write off of the engine.
When you run high compression or a supercharger/turbocharger you are flirting with detonation in order to get maximum performance of every cubic inch of the engine.
Detonation in a high out put engine usually ends up bad.
And all of that extra force on the bearings, piston heads, rings, etc. will cause additional wear and so the mechanical pieces have to be more robust.
On the other hand, there is more “bang for the buck.”