For example, a few years ago, a major drug company reviewed the published literature on cancer in search of new drug targets. Then, with targets identified, they tried duplicating the key published research -- just to make sure -- and were startled to find that much of that research could not be duplicated. The entire project was then abandoned as a waste of effort.
For a more detailed accounting of the defects in published scientific research, I suggest taking a look at: Erroneous analyses of interactions in neuroscience: a problem of significance and The misuse and abuse of statistics in biomedical research.
Peer Review seems to be largely Pal Review. Some cases of Open Review seem to have emerged and could be a better system.