You must be a Grant writer....
According to my Dr. Dung Flung, I became a vegetarian because I sucked hind tit when I was young. Go green!
I cannot help myself, it is regimen not regime. You would think a science writer might know the difference.
Binucleated?
Whoo do I sue? Is there a cure?
A HUgh development binucletally speaking, of course. Wow.
Nat Commun. 2016 Apr 22;7:11400. doi: 10.1038/ncomms11400.
Essential role for a novel population of binucleated mammary epithelial cells in lactation.
Rios AC1,2, Fu NY1,2, Jamieson PR1, Pal B1,2, Whitehead L3, Nicholas KR4, Lindeman GJ1,5,6, Visvader JE1,2.
Abstract
The mammary gland represents a unique tissue to study organogenesis as it predominantly develops in the post-natal animal and undergoes dramatic morphogenetic changes during puberty and the reproductive cycle. The physiological function of the mammary gland is to produce milk to sustain the newborn. Here we view the lactating gland through three-dimensional confocal imaging of intact tissue. We observed that the majority of secretory alveolar cells are binucleated. These cells first arise in very late pregnancy due to failure of cytokinesis and are larger than mononucleated cells. Augmented expression of Aurora kinase-A and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells. Our findings demonstrate an important physiological role for polyploid mammary epithelial cells in lactation, and based on their presence in five different species, suggest that binucleated cells evolved to maximize milk production and promote the survival of offspring across all mammalian species.
I wonder if, when this process of bi-nucleation is thwarted in abortion, there is a mechanism triggered for breast cancer?
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