Actually, it's not meaningless at all - at least conceptually. If you distill it down further into the question of whether there is any reason for, or meaning in existence it becomes much more difficult to justify the hypothesis that there is no reason that anything exists. Scientifically, it requires profound leaps of faith.
All science, even mathematics, is at some level observational, and we only know what our senses allow us to ‘see’ and our brain capacity allows us to understand. Hopefully we are able to understand a lot more than we do now, but the evidence backs up the presumption that we know an infinitesimal amount of what is knowable. To know so little, but to be dogmatic about something as fundamental as the reason and meaning of existence, is non-fact based and by definition a belief of ‘faith’.
You never addressed the meme that faith can be quantified and measured against another “quantity” of faith.