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“In nature humans were generally half starved most of the time. So our bodies are designed to store any extra calories as fat. They do it very well. Too well when we have unlimited food available.”

In nature the food supplies were usually not overgenerous with carbohydrates the way they are superabundant in the current modern diets. This superabundance of carbohydrates in the diet has sent insulin levels through the metabolic roof to the point it causes very serious levels of metabolic syndrome. Such high levels of insulin block the hormones used to signal the metabolism to release fat from storage in the adipose tissues to burn as fuel, Ketones. Consequently, no matter how much a person with metabolic syndrome diets and exercises, the metabolism burns carbohydrates, stores extra carbohydrates as fat in the adipose tissues, or burns the protein in the muscles after converting them to glucose, while locking away the fats in the adipose tissues with fanatical determination to keep them from being used as fuel. The end result is a person with a huge or obese belly even while having stick thin legs, arms, and skeleton like the starving children in Africa. This is a very real metabolic disease which no amount of dieting of calories and exercise can fix. It can be fixed only by not going into a state of metabolic syndrome that prevents fats from being burned off of the body.

Agree with your post, however I gave up on all the "TCA" experts here.

I would add that Metabolic Syndrome will also manifest itself in an even worsening state of health for the American population. That is when Type 2 diabetes starts to develop into Type 3. That is ignoring all the other insulin based inflammatory damage to the human body. Add in the madness of CoA reductase drugs and many people are in for a future of suffering.

For your reference I have been working on a medical grant for a pyruvate type disorder. I am looking closing at Medium Chain Triglycerides (MCT).

Medium-chain triglycerides

C8 MCT is particularly important as we age. It can be found at Amazon (like most of the world lately).

C8 MCT OIL - Caprylic Acid

Our Pseudo "exercise and small portions" experts are going to get a lot of people killed and cause a great deal of suffering.

There is a growing body of evidence that many neurological disorders, particularly with brain iron accumulation are in reality metabolic disorders. No amount of "exercise and small portions" would have prevented them. These disorders may all benefit from ketogenic diets with the inclusion of MCT 7, 8 and 10. There is also a growing body of evidence that a modified ketogenic diet may have prevented or reduced disease severity. Further, ketogenic diets have also been found to dramatically reduce brain injury during ischemic stroke.