Our (2001) F150 will hit 300K next year...no plans to dump it. Maybe get a new engine when needed.
When I buy a new vehicle, I drive it until the wheels fall off. Other than junk, it has no resale value.
Every time I think about a new engine, I tally up that cost and the other worn-out annoyances (thread-bare seats) and decide it is way too much to put into an old vehicle. We typically sell them around 200k and get something used w 30k on the clock. Except this spring we got a super deal for a Mercedes baby SUV that was a loaner at the dealership (10k on it). It came w full new car warranty.