[bigbob]

And for the drones that fly preprogrammed courses without need for a remote driver?

[Larry Lucido]

A nuclear airburst will disrupt their circuitry.

Of course, it would also cause other incidental damage.

[FreedomOfExpression]

And for the drones that fly preprogrammed courses without need for a remote driver?

An EMP of high enough power would fry the electronics.
I'd love to have detailed plans for such a device.