Anyone can get used to anything. People get used to lighter weight guns, but there isn’t that much difference between, say a Glock 17 and a smaller 1911. IIRC, the Glock 17 is around 22 ounces without the magazine.
My go-to carry is my 1911, and it is perfect. I’m a petite woman just over 5 feet tall. Unloaded, mine weighs 25 ounces, stock. With my grips and the magazine (7+1), I’m guessing a bit over two pounds (32 ounces).
It feels fine concealed - not too heavy. I normally carry an extra magazine, too.
I occasionally carry a full sized Kimber 1911. The weight is fine, but I find it harder to conceal naturally because I’m short.
I can shoot just about anything. But carry is another thing. My back is a chiropractic nightmare. And my hips are non existent so things on a belt tend to slide down. I used to carry a redhawk .44 magnum hunting back 20 years or so ago. Well over 50 ounces it was not fun to carry but doable back in my mid fourties. Now, when I do carry (pretty safe community here.....so far) it is a little Colt Mustang.380 I slip in my ubiquitous utility vest pocket. It would be great to be young again