I read a study (cannot remember where) that concluded that natural keyboards were actually not good to use.
Keyboards with angled keys resulted in the user typing with his wrists angled or his elbows out.
You can see why by curling your fingers. Now look at your palm. Notice how your fingers naturally aren’t equally distant from your wrist ? Now imagine your fingers on a natural keyboard. Your wrist will either be bent or your elbows will be out. Neither of these positions are good.
I do not think that would be much of a problem for me much as due to my fingers being stiff and short then I cannot anchor my hands to the keyboard, but the problem might be with the division in the middle. And i usually use my left hand to hit the Y and H keys, or just one key when my hand is on the mouse, but i could adapt.