CORRECTION: toll = TOOL
Yes . . . and no.
All other things being equal, I'd recommend that a healthy man age 21-55 in a gun-friendly state own real weapons: a 9 mm or .45 handgun, a 12 gauge shotgun, and a 30-06, 30-30, or .308 rifle, along with the .22LR rifle and/or handgun, and depend on the centerfire rifle for long-range defense and big game, the shotgun for home defense and waterfowl, and the pistol for carry. The .22 would be my last choice for self-defense. All other things are not necessarily equal. I have close friends who depend on Krav and other unarmed techniques because of local laws. I have relatives, including my father, who no longer shoot anything bigger than .22lr because of health constraints. There are a whole lot of adequate reasons for compromising on a .22lr, and planning to empty all 8/9/10/12/whatever chambers or a 25 round magazine if needed to stop a threat, given internal or external limitations.