No experience with some of the weirder new stuff, but all the native folks in the New World knew the role of tobacco in modulating peyote (mescaline), psilocybin mushrooms, and ayahuasca (harmaline + DMT).
Some of the really strong native tobaccos by themselves contain at least a useful amount of DMT, BTW - but even without that, tobacco alone was/is often used ritualistically as the truly great medicine for the direct link to the Great Spirit in prayer.
That dovetails with widespread anecdotal tales of mood modulation, if you’re tired it helps keep you alert, upset it helps calm you down, etc.
“No experience with some of the weirder new stuff,”
Don’t go there. My recolection is the first products to appear were from Pakistan, later from India.
Had a bud take a shotgun to his wife and best friend, in bed together. He was not a violent guy.
Maybe that was rational.
Had a relative relate his encounter with a demonic entity
I read of a couple of instances of, uh, assailants eating the face off of victims.