Indians used to use tobacco as an antiseptic dressing for wounds.
My first summer job as a teen was working in the tobacco fields and barns of family and neighbors. I know that nicotine will absorb through wet clothing and into your skin. Getting a heavy dose of it pulling tobacco in the morning while the dew is still heavy will make the world spin out from under your feet, quite ill, akin to motion sickness. Smokers didn’t experience this though, only nonsmokers did.