Family guy is hilarious. Particularly after visiting Colorado. Simpsons, Futurama are good as well.
To each his own. The few times I've seen snippets of Family Guy, the attempts at "humor" remind me of the sort of jokes some college freshman would try telling after his first drinking binge.
The Simpsons were actually funny and clever in their early years, now they're unwatchable, to a large part because their writers had to compete with ever more crude and largely mindless humor from other adult-oriented cartoons.