.45 ACP remains my favorite caliber. I have a P220 but find it hard to carry for CCW. About the largest I can go is a P229.
I have 4 scenarios:
1-To and from work...can’t carry.
2-Mountains/wildlife protection .357 in S&W 686, 7 rd.
Shoulder Holster
3-Sketchy neighborhoods CCW .45 Sig P220 Carry, 5 o’clock IWB
4-Just being prudent, extended CCW periods FNS-9, 5 o’clock IWB