"Running up" happens a lot in college football due to school rivalries, the coach's egos, and the way the BCS system works.
This instance is simply one team being a lot better than another. The winning coach actually took measures to slow down the scoring. But he wasn't about to tell some third-string running back to take a knee or a defensive lineman who never plays to NOT sack the other QB.
Injuries occur when you don’t go all out.