No criticism here, just wondering why you are fixated on a .45?
Control is the key to surviving an event. Hitting your target is all about control.
If you have a very powerful hand grip, go for it. If not, don’t.
Try this: take a double action revolver, (a model 19 is what the FBI used to use for this test.) put spring caps in it.
Pull the trigger in double action for one full minute. If you can’t fire that weapon more than 60 cycles in that minute, your hand isn’t strong enough for good weapon control.
If you play tennis, or use a spring hand exerciser, you may be able to control a .45.
If not, bigger is NOT always better, hitting your target is way more important.
More stopping power than a .357? I am not sure, not being a shooter or a hunter. I just read the news everyday and fear what is coming.
Your point about hand strength is a good one. That is definitely an issue for me. I have had hand operations in both hands.