We have a little 3 pound poodle. That combo distemper injection gets her. She screams if you touch her for a few days. We have to pre- treat with Metacam and continue that for a couple of days afterward.
Be careful with the metacam.
http://www.dogs4dogs.com/blog/2012/08/08/help-end-over-vaccination-of-our-dogs-and-cats/
http://www.whole-dog-journal.com/issues/13_8/features/Annual-Pet-Vaccinations_20036-1.html