I saw more of the "cats" back in MN (which the DNR there tries to deny) than I have ever seen in WY. No grizzly sightings yet in WY (we had numerous black bears visit in MN). But I probably would react the same seeing a grizzly as I did on the Yellowstone road --- crouch down in abject fear !!
While not treacherous, do a search on Peach Springs, AZ. It’s the only place where you can drive your personal vehicle to the bottom of the Grand Canyon.
It’s on a poor reservation, but the motel there is very nice. Highly recommend it.