[rmlew]

On the gaming side both NVIDIA and AMD have high end cards which can handle that resolution, although you will want a 690, a NVidia 680 in SLI or a AMD 7970 in Crossfire.
http://www.brightsideofnews.com/news/2012/6/18/the-4k-graphics-card-shootout.aspx

A quick look and NVidia shows that the NVIDIA Quadro K5000 does 4K. Of course, it costs a mint.

[Wonder Warthog]

Good info.....thanks.

If one is doing 3D drawings (Solidworks and similar), a card optimized for rapid rendering for gaming typically also boosts CAD performance.