This is an interesting review article.
Besides making the case against fructose consumption, it suggests that "humans have no functional uricase due to a mutation that occurred in the Miocene epoch," and the "the mutational loss of vitamin C synthesis during the Eocene," could be involved with obesity, metabolic syndrome, aka syndrome X, and type 2 diabetes.
It took me about 3 hours to read.
In answer to the obvious question, people in the Arctic get their vitamin c from seal skin.
Next question, why do some people use Vitamin B-12 supplements? And no, it's not 'cause they're crazy ~ rather, they have a B-12 leak somewhere in their metabolism and need to consume more of it than the average human could use. Just noticed the Vitamin C's trick with us is a high retention rate from dietary sources just like B-12 ~ so that mechanism was there all along ~ might look at the chemistry to see if the B-12 'leakage' is related to something to do with various types of sugar. undoubtedly some poor grad student somewhere is doing daily blood tests on his crazy uncle they keep in the attic!
Real quickie on uricase, primates don’t have the gene either ~ so this is an oldie ~ and all our wild cousins with small brains are consuming fructose day and night anyway!
I think we’ll see the a calorie is a calorie model go out the window. How we metabolize what we eat is the critical factor in human health.
One other aside, you should talk to a large animal vet. Veterinarians solve most animal illnesses with minerals. That’s what one told me. He said he doesn’t understand why doctors don’t look into mineral deficiencies as a root cause of many illnesses.
Given that these threads always involve mineral and vitamin discussions I wonder if someone could bridge the gap?