[Yaelle]

Now Kelsey Grammer—there is a guy who knew how to leverage a supporting role! I read somewhere his net worth is $80M.

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Yes, he as achieved the ultimate! Is there another actor who was a side character on a series, then became a Name Lead in a decade running live sitcom, then was syndicated and on 3 times a day, tried out multiple other lead series, and finally found one with a character so vastly different you can’t believe it’s the same guy??

[rbg81]

WRT Kelsey Grammer, when “Frazier” first aired, the actor who plays Niles Crane (David Hyde Pierce) looked & acted so much like him, I thought they really were brothers. Always thought that the most inspired casting I ever saw TV wise.

[Lancey Howard]

Is there another actor who was a side character on a series, then became a Name Lead in a decade running live sitcom, then was syndicated and on 3 times a day, tried out multiple other lead series, and finally found one with a character so vastly different you can’t believe it’s the same guy??

Yep.
Jerry Seinfeld's dentist, Tim Whatley comes to mind. From a sitcom dentist, to a sitcom dad to... Walter White, meth cook extraordinaire?