Unless we are going to have selective enforcement of federal law, I would say, “Change the federal law to allow states to “experiment””.
That said, I would cut the fed funds for the DEA and direct them to concentrate on the big fish who import the deadliest drugs.
For example, the largest drug money launderer in America has continued his very lucrative business for over 20 years through dim and pubbie administrations without an investigation. Newspaper reporters have privately told me that the operation is well known, but their editors have forbidden them to investigate or write about what they know.
The corruption of the system by bribes and intimidation are the core of our problem. For example, why did the fedgov suddenly decide to crack down on California’s medical MJ outlets? Could it be because the cartels were seeing a drop in sales?
To me, this is the MOST important reason to attack the demand for drugs. Take the profit out of heroin and you hurt the Taliban, organized crime, crooked pols, crooked cops, et al.
IOW, piss on the Tenth Amendment. Let big daddy fedgov use the expansive Commerce Clause to ‘allow’ states to experiment as much or little as it sees fit.