where does the wild variety grow?
http://www.gardenguides.com/taxonomy/aztec-tobacco-nicotiana-rustica/
“Wild tobacco is native to the southwestern United States, Mexico and parts of South America. Given proper care, this species can be grown throughout the continental United States.”
You can buy starter seed online (one example):
http://www.victoryseeds.com/nicotiana_rustica.html
Speaking from personal experience, it should be treated like any potentially toxic plant, such as foxglove (which is really pretty and contains digitalis), monkshood, oleander, jimson weed (datura), etc. That is, children and dogs that eat plants should not be around them unattended, and gloves should be used while working with them.