No spaecraft will make it that far. Cosmic radiation bursts will kill off the crew, or low/no gravity will
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No current craft. But a steerable version of Dyson’s Orion would easily overcome both problems. Was on drawing boards in the late 60s. Killed by Nixonian politics.
The ship would have to be large enough to accommodate many generations - and food for hundred - if not thousands of years.... Propulsion isn't the only problem here...
Orion would still take years to get to the closest star. And to say that their equipment would work as long as it needed to without repair or ability to repair....
If I remember the orion was the slowest of a bunch of different versions of spacecraft, that wouldn’t go above .02-.04c.
And if it was the version that used nuclear explosions to detonate behind it to push its driver plate, how many of those would they have, and how many could they carry before running out? The other thing was that it had to be very heavily shielded because of the nuclear explosions it used to propel it.