Have you tried a flat mainspring housing? I have small to medium hands and I put the flat housing on all my 1911’s. I have a Light Weight Commander that feels like it was born in my hand.
naw....the only guns that feel uncomfortable in my mitts are my pocket pistols...they are too small and my bottom finger has to tuck under the grip. I had to put oversize grips on my Model 19 S&W.