I don’t use a hot sauce in making chili, I use chili peppers and/or chili powder. The hot sauce goes on top, Crystal, along with the diced onion, shredded cheddar and sour cream. It’s got just the right “mmmm” cayenne thing going on, not vinegar or an overpowering separate taste. I’ve just not been taken with Frank’s for much of anything, it’s the normal orange restaurant/bar hot wing sauce, nothing more and nothing less. McIlhenny Tabasco is great to cook with for certain things, but not quite as good for a condiment, imho.
I use dried chilis, chili powder, cayenne, pepper flakes, and when I can get ‘em, hot fresh green chilis that I scorch, sweat and puree and throw in. And hot sauce, paprika, Mexican oregano, cumin, garlic powder.