Actually not to bad try the Alaskan Survival one with one barrel chambered for 45/70 that is one gun I thought had blown my hand off!
I have been thru about all of them 44 mag,454,460 ruger,480,357, came back to what I began with 45LC large caliber lots of knock down power but easy to control and can change out with my rifle, I have a Puma lever action chambered in 454 Casull will also take 45LC either will take about any game around.
I have that derringer in .45 APC and .410 and have tried to fire it for accuracy at short range. By short range I mean about 6 feet. At that distance I can reliably put a bullet within about a foot circular of where I am aiming. The recoil is pretty intense and I didn’t perform this experiment very many times. Like I said, I think of it as a power knife.