Odds say there is sentient life somewhere else in the universe.
We can’t rationally asses the odds because despite some imaginative guesses we don’t know how life begins. And we currently can’t imagine any kind of life except our own DNA based life though we don’t know that it’s the only basis of life.
Disagree.
The only way we would not be able to calculate the odds of life existing in the universe is if life didn’t exist somewhere in the universe.