No, I don't think Virginia Creeper makes the skin itch. The berries have oxalic acid, so would give you a belly-ache if you ate a bunch ...but most people wouldn't be tempted, and the birds eat them happily and readily. And poop out the seeds, which I think is one reason why it spreads so much. I'm trying to get rid of The Creeper because it's covering walls and utility poles and is threatening to take down our telephone and electrical wires.
And it's actually mixed in with the Poison Ivy, which makes pulling hazardous. In the Fall when it gets cooler, I'm going to hit the biggest clumps with Round-Up. And after it visibly dies down, I'll send out #2 Son dressed in long sleeves and pants, and gloves, to pull and tear away.