.22 semi autos?
Target and hunting: Browning Buckmark or Ruger MkIII or 22/45
One thing I prefer about the Buckmark over the Ruger is the ATF registered part is the frame, so you can buy Buckmark barrels without doing paperwork, even over the internet. You can get longer heavy barrel for target, light long barrel for hunting, short barrel for plinking and easily swap them out.
Conceal carry: Beretta. Several models from the tiny Tomcat to a .22 LR version of their .380 that looks like a smaller M9/Model 92. I think it’s a model 86.
altho i’ve heard lots and lots good of the ruger mkiii i’ve never been able to (personally) get over the grip angle- naturally aligning the gun points high for me. the buckmark is an equal gun, but has a grip angle patterned after the 1911, and seems to point better.
All firearms are serialized on the Frame/Receiver (post 1964) any other numbers have no value as to the ATF