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In other words, Cancer gets away with being a ‘high crime neighborhood’ because they ‘shot the local cop’. p53 being the local policeman in this scenario.

Worse, it says the mutated p53 goes Quisling to aid the cancerous tumor.

Yes indeed, that is the new twist; that in many cases the mutated p53 aggregates and sucks up any activated p53 that might have still been around and otherwise makes the cancer worse.

Aggregates of the protein Huntingtinin in the brain are what causes the eventual insanity and death of Huntington's disease. This is because the codon triplet “CAG” (that specifies the amino acid glutamine) is ‘slippery’ and DNA polymerase will sometimes add an extra one. The gene for Huntingtinin usually has a few “CAG” repeats in normal people, those with the disease have many “CAG” repeats.

Worse still is the propensity of a long chain of “CAG”’s to become even MORE inclined to ‘slip in’ an extra “CAG” or two when the DNA is copied. Sort of like if I said “cat cat cat cat cat cat cat cat cat cat cat” really fast, you might not be sure if I said it 11 times or 12 times - so DNA polymerase becomes even MORE likely to add a “CAG” every time - and soon like a ‘crazy cat lady’ you have WAY TOO MANY “CAG”’s.

Hyper glutanation of proteins (CAG ‘spells’ glutamine in the language of genetics) commonly causes aggregation of proteins - glutamine to glutamine, in more than just Huntingtinin.