I suspect that for CFS, this might be caused by XMRV virus. Post-lyme folks are reported to test positive for XMRV at high rates, too, IIRC.
Wonder if this might have application to the mysterious “Morgellon’s Disease”, which does seem to be linked in some cases to Lyme.
Ah cause for hope and help. Debilitating pain and overwhelming fatigue are most difficult especially with the ongoing controversy and lack of effective treatment regimens.