[Opinionated Blowhard]

LOL. I know someone who swore by them. I have to find their email and send them this article. I guess, ironically, it did work for my friend even if it has no real effect. “Placebo Effect” indeed.

[oh8eleven]

I've never used glucosamine and chondroitin, but I have used other dietary supplements which have also been "proven" not to work. The alternative was a prescription drug with a number of side effects.
The supplements worked for me with no side effects and when my doctor claimed it was probably just a placebo effect, I asked him what's the difference if they work? No reply.