At our old house we had Bougainvillea which were pretty but not edible. Thorns were up to two inches long.
Perhaps the Bougainvillea on the outside row and blackberry on the inside so you can get the berries?
I read an article not too long ago on Survival Blog about this very topic...natural barriers. They also recommended bamboo, planted closely together, along the perimeter, presumably as an anti-vehicle and anti-horseback barrier. The great thing about bamboo is it can be used to make tools, housing, etc. Of course, it grows like the dickens, so until TSHTF, you'd have your hands full controlling it. Believe it or not, it even grows in the mountains here in Idaho.
Scouts Out! Cavalry Ho!
Flowering Quince is a beautiful shrub, has needle sharp thorns about 1 to 2 inches long...slow grower tho, but its hard to even pull weeds around one....They will continue to grow and I have seen some 8 foot tall...but those are quite old..