Do you mean defending your home or defending yourself in your home?
If you mean the first. I must ask. Is your home defensible?
As for the second I have a Winchester Defender 8 shot, but post 27 sounds like a better option to me. I've wanted to try Dragon's Breath, a zirconium-based pyrotechnic shotgun round. Might be good for getting the fire at camp going. Post 110 is right on.
What if the bad guy is wearing kevlar?
Seriously, there are many folks out there that may have vests and such to protect their vitals. The stuff isn’t prevalent, but it’s not unobtainable either.