Notre Dame has already had their chance a number of years ago when they were invited to join the Big 10. There are 2 reasons why Notre Dame will not join the Big 10 or any other conference right now for football.
1. Their $50 Million per year contract with NBC.
2. Their deal in the BCS. If Notre Dame makes a BCS bowl, they are guaranteed $10 million. If they do not make a BCS bowl, they still get $1.5 Million.
With the exception of Football and hockey, Notre Dame is a member of the Big East. Football, they are an independent. Hockey, they are a member of the CCHA.
Unless the Big 12 gains the majority of the Mountain West members, I would like to see Iowa State and Missouri in the Big 10. Kansas and Kansas State also might be interesting.