Scientists discover cause of destructive inflammations

Helmholtz Association of German Research Centres ^ | Mar 3, 2010 | Unknown

[decimon]

Kill the messenger ping.

[massmike]

save for later

[Marylander]

Awesome.

[verity]

It should be renamed the ‘Obama’ molecule.

[r9etb]

In mice, the researchers found ...

Mouse studies are always suggestive, but often don't carry over to humans. We can hope they're right, but I wouldn't hold my breath.

[r9etb]

Kill the messenger ping.

lol.... clever!

[mewzilla]

I wonder if this could be applied in the treatment of Alzheimer’s Disease?

[hennie pennie]

Fascinating finding here.

[TChris]

AFAIK, Alzheimer’s isn’t an inflammatory condition.

[JoeProBono]

Thanks for the ping.

[decimon]

I wonder if this could be applied in the treatment of Alzheimer’s Disease?

I don't know but this looks like a discovery that might apply to many ailments.

[mouse_35]

I hope something comes from this. My mother-in-law, my husband and my daughter all have auto-immune disorders.

[sig226]

IIRC, Alzheimer’s is caused by tangled proteins in the brain, not an autoimmune reaction. It does have potential applicability in other diseases, though. Diabetes, Lupus, Myasthenia Gravis, Rhuematoid Arthritis, Psoriasis, and maybe Schizophrenia are thought to be autoimmune disorders. Controlling the immune system has wide reaching implications.

[mad_as_he$$]

ping

[mouske]

“It does have potential applicability in other diseases, though. Diabetes, Lupus, Myasthenia Gravis, Rhuematoid Arthritis, Psoriasis, and...”

As I can only hope - ankylosing spondylitis.

[PeaceBeWithYou]

Hmmmmm.

Seemed odd to include a link to a picture, but not after seeing it. ;-)

[novemberslady]

Bkmk
Thanks for posting this.

[allmendream]

The only better model systems than rats and mice are non-human primates, and that is because the close genetic similarity we share with rats and mice is even greater between us and other primates.

Usually rats and mice are used for initial studies because they are inexpensive. These studies are then confirmed in a non rodent animal model (usually dogs), then in non-human primates, then tested in humans.

Only if the treatment is found to be efficacious in rodents will it usually be moved on to NH-primates and then humans.

The CD proteins are likely to be very similar between all these species, so the molecular interactions should be similar enough to maintain efficacy.

[r9etb]

The only better model systems than rats and mice are non-human primates, and that is because the close genetic similarity we share with rats and mice is even greater between us and other primates.

In Type I diabetes studies, at least, mouse results are notorious for not carrying over well into humans.

Given that Type I diabetes and the inflammation response reported here are both autoimmune responses, I have a strong suspicion that the results reported here will similarly not carry over well to humans.