http://en.wikipedia.org/wiki/Smallpox
In 1992 Soviet defector Ken Alibek confirmed that the Soviet bioweapons program at Zagorsk had produced a large stockpileas much as twenty tonsof weaponized smallpox (possibly engineered to resist vaccines), along with refrigerated warheads to deliver it. It is not known whether these stockpiles still exist in Russia.
With the breakup of the Soviet Union and unemployment of many of the weapons program's scientists, there is concern that smallpox and the expertise to weaponize it may have become available to other governments or terrorist groups who might wish to use virus as means of biological warfare.