For close range self-defense - How about ‘The Judge’ Taurus .45/410 Revolver...?
(http://www.taurus-handguns.com/item/167268_Taurus_Hand_Guns_Pistols_TAU_2441031TC_____M410_45.aspx)
That’s a cool one. I was worried about this. There are so many good choices. Am I the only one who thinks it’s weird that it’s illegal to saw off a shotgun, but perfectly legal to make a pistol that shoots shotgun shells?