Absolutely! :-)
But...Already there are pearls of wisdom!
For a Lady I would go with a handgun-rifle combo Taurus Judge in 410+45 and some type of 45 lever gun for the rifle that way you can use the 45 ammo for both the handgun and the rifle plenty of knockdown power with both and the Judge will handle the 410 shot shell in any shot size from OO to bird-shot or the 45 LC very effective in close quarter’s.
I love the old 45 long colt it has been around a long time and will be around a lot longer I have used all the other types over the year’s 357mag 44mag 327mag 38 22 in all types and model’s of guns and prefer to carry for personal protection the old tried and true 45 long colt.
The 45 lc has lots of bang and lots of power but is low on recoil I think that is what you are looking for something that won’t kick to bad. the AR is a good choice but is also hi maintenance look at that also can you take it down and put it back together with an AR that’s done a lot !