Buffy the Vampire Slayer -— Crosses work a little. Vampires get burned by it, but can simply ignore the pain.
True Blood — Crosses are irrelevant ( and Vampires are now OPENLY living among humans ).
In the book "I am Legend" the vampires created by the plague were impacted by the symbols of the religion they had before they became vampires. So one vamp is terrified of the Torah. I thought that was clever and consistent with the book's theme that vampirism was a disease.