Progress in application compatibility according to test results from Wine AppDB.
(silver)Software that runs flawlessly
(yellow) Software that runs flawlessly with configuration
(gray) Software with minor Issues
(orange) Software with major Issues
(tan) Unusable software
More and more of your Windows software can run flawlessly on Linux+WINE with no tweaking needed. Just install WINE, install the software, and run as you normally would. Yes, even graphic-intensive software (i.e. games, visualization, 3d-rendering, photo/movie editing).