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What I'm telling you is that fructose is metabolized in a different manner than glucose or sucrose and as such, some people have difficulty in maintaining a proper blood sugar level.

If you don't even know that 50% of sucrose is made from fructose then it will be impossible for you to understand that a healthy body should have no problems maintaining a proper blood sugar level. To really understand nutrition and physiology you have to have some knowledge of it.

The point is that many food product manufacturers went about replacing sucrose with fructose as if it were exactly the same thing. It isn't.

You're embarrassing yourself. Sucrose is made up of two chemicals (glucose and fructose) in equal proportions (50% each). High fructose corn syrup is commercialized in two forms. One is 42% fructose and 58% glucose while the other is 55% fructose and 45% glucose. When food manufacturers replaced sucrose (table sugar) with high fructose corn syrup, they didn't change the two chemicals you consume. They are essentially the same thing and your body cannot distinguish between fructose and glucose from HFCS and fructose and glucose from sucrose. I can't make it any simpler than that.

Different sugars are processed differently by the body.

So what? They're all carbohydrates and offer 4 calories per gram. Why is that scary?

The amount of that difference varies from person to person.

Huh? Some people get more than 4 calories per gram from the same carb and some get less? What do you mean by this? Do you even know?

To say in a general statement that the only reason people are obese is because they eat too much is just dumb.

Really? Then explain to me how burning more calories than you consume will cause you to gain weight. You could become the first person to disprove the first law of thermodynamics.

Granted, for many people, the way the body converts fructose versus sucrose makes a negligible difference. But for others, the difference between the body's reaction to consuming fructose and sucrose can cause all manner of difficulty.

You don't even know that sucrose is comprised of fructose and you want me to believe you when you say that consuming fructose (and sucrose LOL!) can cause all sorts of difficulties. I am noting here that you've said nothing thus far about people who may suffer from fructose intolerance.

Yes and if I pee in your soup it's all going to end up with you peeing the liquid out.

You think it's immaterial that glucose and fructose both end up in the Krebs cycle as 3x2 carbon fragments? Did you struggle in school with biology and chemistry?

So, unless you want to claim that the American Journal of Clinical Nutrition is just another "wacky website" you might want to tone down your attitude and do some reading.

If I thought you had any understanding of the abstract you linked I'd be happy to go into detail as to why this research does not support your suggestions.

"Both plasma insulin and leptin act in the central nervous system in the long-term regulation of energy homeostasis. Because fructose does not stimulate insulin secretion from pancreatic ß cells, the consumption of foods and beverages containing fructose produces smaller postprandial insulin excursions than does consumption of glucose-containing carbohydrate.”

As long as it is fructose it doesn’t stimulate insulin. This statement, however, is highly biased since fructose is quickly converted into glucose by the liver which then stimulates the release of insulin. This is agenda driven research designed to influence the reader into a desired conclusion.

Because leptin production is regulated by insulin responses to meals, fructose consumption also reduces circulating leptin concentrations. The combined effects of lowered circulating leptin and insulin in individuals who consume diets that are high in dietary fructose could therefore increase the likelihood of weight gain and its associated metabolic sequelae. In addition, fructose, compared with glucose, is preferentially metabolized to lipid in the liver. Fructose consumption induces insulin resistance, impaired glucose tolerance, hyperinsulinemia, hypertriacylglycerolemia, and hypertension in animal models."

In animal models? How much of their diet consisted of fructose? Does this reflect similar consumption by the average human? Were the lab animals fed straight fructose or fructose in combination with glucose? You can create all kinds of desired results by managing the intake. Would a researcher be more interested in obtaining grant money than reporting the truth? Naw, that never happens. How would you even know? Tell us about all the time you spent in research focused on food ingredients.

Kathleen J Melanson and others at Rhode Island University reviewed the effects of HFCS and sucrose on circulating levels of glucose, leptin, insulin and ghrelin in a study group of lean women. All four tested substances have been hypothesized to play a role in metabolism and obesity. The study found "no differences in the metabolic effects" of HFCS and sucrose in this short-term study, and called for further similar studies of obese individuals and males. ("Similar effects of high fructose corn syrup and sucrose consumption on circulating levels of glucose, leptin, insulin and ghrelin,"

HFCS and sugar have similar metabolic mechanisms (Friday, April 07, 2006)

So, unless you want to claim that the American Journal of Clinical Nutrition is just another "wacky website" you might want to tone down your attitude and do some reading

Thanks but I’ve done plenty of reading over the years and understand that the linked research you cite doesn’t prove what you think it does. Now, maybe you could cut and paste the part of the study that proves the "metabolic mechanism" in HFCS makes people lose all sense of fullness thereby preventing them from being able to stop eating. At least your most recent citation will understand that corn syrup is made up mostly of glucose, not fructose. It’s pretty basic stuff really. How long did you have to Google to find this report? Do you still think that fruit, fruit juice, honey and table sugar are dangerous substances that should be avoided? At some point you need to realize that too much of anything can be bad for you – especially if you’re a lab rat in an experiment being conducted by someone desperate for more grant money.

My wife had the darndest time losing weight, even on an 800 calorie a day diet.

I don’t know her metabolic rate or what her diet consisted of but I think you need at least that amount of calories a day just to maintain body heat. She must have been highly lethargic.

By eliminating all most complex carbohydrates and returning to a diet in meats, vegetables and simple sugars she lost 110 lbs.

Simple carbs resulted in weight loss and no insulin resistance while complex carbs caused insulin resistance and weight gain? People wanting a catabolic diet will prefer complex carbs from vegetables that burn more calories than they offer. Vegetables high in fiber (most vegetables) are good for this. Why she could lose weight eating protein and simple carbs but not protein and complex carbs is a mystery. Of course, I don’t know what she was consuming when she subsisted on 800 calories a day. There’s something not right about your story but at least she’s much healthier now than before.

I’m surprised Duke Medical told you it was fructose that caused her insulin resistance rather than her obesity and sedentary lifestyle. Is that what they told you? I ask only because it seems to be what you’re implying.

So who am I going to believe, you, or my lying eyes, Duke University Medical Center and the American Journal of Clinical Nutrition?

You don’t even understand that sucrose is half fructose so I’d be surprised if you understood much of what the folks over at Duke Medical told you. And I know for a fact that you don’t understand the research you Googled from the AJCN this time around. But that’s neither here nor there. The bottom line is that HFCS and sugar (sucrose) are made up of the same two chemicals, in almost identical proportions, and to your body the source of those chemicals is indistinguishable and unimportant. Eating HFCS instead of sucrose doesn’t stymie any satiation mechanisms and does not cause people to keep stuffing their faces.