I’ve been on Vista for about 3 weeks now (on an Intel i7 box) and have discovered it doesn’t support a plain-Jane Seagate FreeAgent USB hard drive .... after 1 1/2 years of complaints from users!!!
Nothing wrong with the drive, it works on all of my non-Vista computers.
Vista has some nifty features, especially on i7 and Radeon 4850 graphics, but its compatibility with normal everyday stuff sometimes falls short.