[Coleus]

Multiple Sclerosis Reversed in Patients Taking Own Stem Cells  

Jan. 29 (Bloomberg) -- Patients in the early stages of multiple sclerosis had their disability reversed in a study that used their stem cells to “reset” their malfunctioning immune system.   All 21 patients in the study at Northwestern University in Chicago had the “relapsing-remitting” form of the disease that makes their symptoms alternately flare up and recede. Three years after being treated, on average, 17 of the patients had improved on tests of their symptoms, 16 had experienced no relapse and none had deteriorated, the study found.  “This is the first study to actually show reversal of disability,” said Richard Burt, an associate professor in the division of immunotherapy at Northwestern, and the lead author of the study published today in the British journal, the Lancet. “Some people had complete disappearance of all symptoms.”

In multiple sclerosis, or MS, a patient’s immune cells attack the central nervous system, degrading their vision, coordination, balance and sometimes their cognitive abilities.  The vast majority of patients with this disease are first diagnosed with the relapsing-remitting form and some progress to more serious stages. The study included only patients whose flare-ups continued after being treated with protein-based drugs known as interferons.  Participants had their hematopoietic, or blood-forming, stem cells extracted before chemotherapy drugs killed immune cells in their bone marrow. The patients’ stem cells were then returned to rebuild their marrow.

Vision Dimmed

One of the patients was Edwin McClure, now a 24-year-old graduate student in marketing at Virginia Commonwealth University in Richmond. McClure was diagnosed with multiple sclerosis as a high school senior in 2002, after his vision dramatically worsened.  “It was like someone had turned down the dimmer switch,” he said in a telephone interview yesterday. He also suffered from dizziness, poor balance and fatigue so bad that he’d collapse and sleep for three hours every day after school.  Over the next few years, McClure was treated with steroids and interferons. While they controlled the disease for a time, his symptoms eventually broke through, triggering fresh attacks.

McClure went to Chicago to take part in Burt’s study at the end of 2005, spent a month being treated, and hasn’t needed any drugs since. 

‘A Blessing’

“It’s a blessing,” he said. “My disease has been halted.”  Even the stress of being in the competitive graduate program -- a factor known to exacerbate symptoms of multiple sclerosis -- hasn’t caused a single attack, he said. His balance is better and his vision hasn’t deteriorated further.  Researchers believe that in the early stage of the disease, the hyperactive immune cells attack nerve cells. This damages the myelin, an insulating material that surrounds the axons, long fiber tails that extend from a neuron and help transmit electrical signals.

“Research has shown it’s critical to stop the inflammation early and that’s probably the best way to stop neural degeneration and progression of the disease,” said Patricia O’Looney, vice president of biomedical research at the National MS Society, in a telephone interview yesterday.  In previous efforts, Burt and other scientists tried giving bone marrow stem cells to patients with more advanced disease, with no benefit.

Late-Stage Failure

“I called it a failure,” he said. “When you do it in late-stage patients, they don’t improve,” probably because the immune cells have already done their damage.  O’Looney said the results of Burt’s study were promising and should now be replicated in a larger trial that randomly compares the stem-cell treatment with existing therapy. Burt is now starting such a trial, which will recruit 55 patients in the U.S., Canada and Brazil.  If the results of today’s study are borne out in the new one, “I think we can really change the way this disease is approached,” Burt said.

[Incorrigible]

I could see how this might stop future attacks but I can’t see how it would fix the already fractured nerve paths.

For the remitting/relapsing type, I’m not sure if this is worth the effort. For the progressive, I think I would take the chance.

I’ll pass it on to the wife.

[waynesa98]

My girlfriend was just diagnosed with MS. Looking at all the options we decided to enroll in a drug trial (Campath) in many ways its the same as the stem cell treatment. The immune system is knocked down stopping the autoimmune attack on the mylinated sheathing of the brain. Just went in for the first screening for the trial, and I must say the doctors were very wary of the study referenced in the article. (Our doctors are from a very famous group of neurologists) Too any one out there with MS there are a number of clinical studies not only with Campath, but also the various other drugs in different combinations. If you are controlled I'd stay with what your doing. If not, there is a campath trial for those that have failed other treatments. There is also a long term monitoring study for those on tysabri that is recruiting(no change in treatment they just want to see how people do over the next 5+ years.